Although the role of the BAFF pathway (BAFF/BAFF-R) has been deeply investigated in relation to several autoimmune diseases, such as rheumatoid arthritis (RA) [15] and systemic lupus erythematosus [16,17], data on primary Sjögren’s disease are mostly limited to soluble BAFF (sBAFF), and the possible correlation between its expression and lymphomagenesis in primary Sjögren’s disease remains to be elucidated. Here, TNFSF13B is linked to systemic lupus erythematosus.