Conversely, primary Sjögren’s disease patients who developed NHL showed lower IgM plasma levels (69.4 ± 16.7 mg/dL) than patients without neoplastic transformation (132.6 ± 12.8 mg/dL; p = 0.03) and sicca disease patients (138.2 ± 12.6 mg/dL; p = 0.02). The gene discussed is CD40LG; the disease is non-Hodgkin lymphoma.