Concerning the role of SMARCA4 in cancer, BRG1 deficiency is implicated in the development of several malignancies, such as small-cell carcinoma of the ovary hypercalcemic type (SCCOHT), SMARCA4-deficient thoracic sarcoma, colorectal cancer, and endometrial stromal sarcomas [32,33,34,35,36]. The gene discussed is SMARCA4; the disease is cancer.