The genomic profiling of archived MCL tumor samples has identified recurrent mutations in the TRAF2, BIRC3, and MAP3K14 genes, suggesting a dependence on either the BCR-BTK-NF-κB (classical) or MAP3K14-NF-κB (alternative) pathways for MCL pathogenesis [90]. The gene discussed is BIRC3; the disease is mantle cell lymphoma.