EP300 and acute myeloid leukemia: Notably, the cooperation of MYB and p300 with members of the CCAAT-box enhancer binding protein (C/EBP) family has been well-established in myeloid-specific gene expression, with recent research showing that certain C/EBPβ inhibitory compounds indirectly suppress the MYB-dependent transcriptional program in AML cells [30,31,32].