In mouse models with IEC-specific deficiencies, caspase-8 deficiency (Casp8fl/fl × Vil1-cre, Casp8IEC-KO) has been reported to develop ileitis [179], as well as impaired mucosal barrier function and bacterial clearance at the epithelial interface, which leads to colitis [180]. This evidence concerns the gene CASP8 and colitis.