MYCN and neuroblastoma: From a systematic analysis of public RNA-seq data (TARGET) on the TME composition in neuroblastoma, it was found that CD8+ T cells, T-helper 17 cells, NKT cells, Tregs, and DCs were significantly more enriched in the group with high-risk neuroblastoma without MYCN amplification compared to the group with high-risk neuroblastoma with MYCN amplification (p < 0.05).