Figure 6A,C show that the concentrations of MMP-3 and MMP-13 were significantly diminished in the O + B100 and O + M groups (p < 0.05). However, the administration of BSRE did not affect the MMP-9 content in serum in the osteoarthritis test group, as seen in Figure 6B. Here, MMP13 is linked to osteoarthritis.