GCG and asthma: In fact, in a murine model of OVA-induced asthma, GLP-1 analog liraglutide significantly reduced airway inflammation, mucus hypersecretion, and elevated levels of E-selectin or MUC5AC mucin [196], whereas another GLP-1R agonist, exendin-4, showed a bronchorelaxant effect, alleviating hyperresponsiveness of human isolated bronchi subjected to passive sensitization and high-glucose concentration [197].