Furthermore, in the murine model of OVA-induced asthma, ghrelin alleviated unfavorable changes in the course of inflammation, including pathologic features in the histological picture, airway hyperresponsiveness, increased number of total and particular leucocytes, and elevated levels of TNF-α, IFN-γ, IL-5, or IL-13 [190]. This evidence concerns the gene IL5 and asthma.