The last pathway database, named Wikipathways, showed significances for: PI3K-Akt signaling pathway (Kinase Ratio: 22/65), Malignant pleural mesothelioma (Kinase Ratio:22/65), Ras signaling (Kinase Ratio: 19/65), Focal adhesion: PI3K-Akt-mTOR-signaling pathway (Kinase Ratio: 18/65), and Hippo signaling regulation pathways (Kinase Ratio: 17/65). The gene discussed is MTOR; the disease is malignant pleural mesothelioma.