Moreover, Shishodia et al. reported that the expression level of miR-21 increases during the transition from low-grade squamous intraepithelial lesions (LSIL) to high-grade squamous intraepithelial lesions (HSIL) and invasive cancer, corresponding to a decreased level of TIMP3 [68]. Here, TIMP3 is linked to squamous cell intraepithelial neoplasia.