PIK3CA and colorectal carcinoma: It has been reported that the inhibition of the Wnt/β-catenin pathway is associated with the upregulation of the PI3K/AKT/mTORC1 pathway in CRC, and blocking the PI3K/AKT/mTORC1 pathway results in Wnt/β-catenin signaling hyperactivation as a compensatory mechanism [135].