CGAS and cancer: Current literature suggests that PARPi may alter how tumor cells evade the immune response by either causing direct cancer cell cytotoxicity or alternative immuno-stimulation (cGAS/STING pathways, paracrine stimulation of DCs, and increased T-cell infiltration) [53], although, as described above, cancers with high population of defective STING signals may be less responsive (i.e., ovarian cancer).