However, research has found that 12 weeks of moderate-intensity exercise can reduce the mRNA expression of transforming growth factor-β (TGF-β) and α-smooth muscle actin in NASH rats, increase the expression of cysteine-rich angiogenic inducer 61 (Cyr61), inhibit HSC activity, and reduce liver fibrosis scores [81]. Here, CCN1 is linked to metabolic dysfunction-associated steatohepatitis.