In studies of exercise combined with dietary intervention, it was found that 14 months of treadmill training or treadmill training combined with DHA feeding can enhance liver LC3II/I and Atg7 expression in elderly DIO mice and reduce p62 protein and pro-inflammatory gene expression such as MCP1, IL6, TNFα, and TLR4 [76], thus alleviating NAFLD progression. Here, SQSTM1 is linked to metabolic dysfunction-associated steatotic liver disease.