It has been confirmed that H2A.J is involved in regulating two important pathways, Mitogen-activated Protein Kinase 7/Extracellular signal Regulated Kinase 5 (MAPK7/ERK5) and Human Immunodeficiency Virus (HIV), Negative Factor (Nef) pathway in CRC, together with the enrichment of several inflammatory pathways to increase CRT resistance in CRC patients (Figure 6) [196]. Here, MAP3K7 is linked to colorectal carcinoma.