Moreover, hypoxic-dependent reduction in H2A.X abundance in hepatocellular carcinoma (HCC) will increase γ-H2A.X level, consequently promoting angiogenic activity and Epidermal Growth Factor Receptor/Hypoxia-Inducible Factor 1 alpha/Vascular Endothelial Growth Factor (EGFR/HIF-1α/VEGF) signaling pathway to gain nutrients (Figure 2B) [54]. The gene discussed is VEGFA; the disease is hepatocellular carcinoma.