CD44 also interacts with other signaling receptors, such as transforming growth factor-β (TGF-β) and epidermal growth factor receptor (EGFR), influencing a variety of cancer signaling cascades (notably PI3 kinase-Akt and MAP kinases pathways) which ultimately lead to chemoresistance, invasion, cell proliferation, and survival [16]. This evidence concerns the gene CD44 and cancer.