However, a preliminary statistical analysis showed that among ACPA+RF+ RA patients, compared to seronegative ones, there was a higher number of individuals with CICs containing 32.7 nm, and 1218 nm, and 1718 nm particles and a lower number of individuals with CICs containing 396 nm particles (Supplementary Materials Table S8). The gene discussed is PRTN3; the disease is rheumatoid arthritis.