IL11 and squamous cell carcinoma: At the end of the IL-11 Mutein treatment, we observed changes in proteins such as Tpp2, which is implicated in cellular division and apoptosis and is significantly increased in squamous cell carcinomas [43], while C1s1 and Gp1ba have been linked to fibroblasts and matrix in other solid tumor types [44,45], suggesting matrix remodeling may occur following treatment.