Pairwise comparison revealed that Hp, transgelin-2 (Tagln2), bridging integrator 2 (Bin2) and mannose-binding protein C (Mbl2) were significantly elevated in the serum of 2-month-old gp130Y757F mice compared to wild-type mice and these differences were exclusive to the early GC disease stage (Figure 1C). This evidence concerns the gene BIN2 and gastric cancer.