The authors demonstrated that YY1 occupancy is observed genome-wide in both typical enhancers and super-enhancers and is likely to be cell type specific, as human ChIP-seq data exhibited patterns of YY1 binding differing between lymphoblastoid cells, colorectal cancer cells, hepatocellular carcinoma cells, embryonic stem cells, T-ALL cells, and CML cells [177]. This evidence concerns the gene YY1 and hepatocellular carcinoma.