HLF and acute lymphoblastic leukemia: In the case of other haematological malignancies, the TCF3-HLF chimeric TF in paediatric acute lymphoblastic leukaemia (ALL) and the ETO2-GLIS2 chimeric TF in paediatric acute megakaryoblastic leukaemia (AMKL) activate MYC expression, which, in turn, accumulates in the SEs of malignant cells, leading to a conserved MYC-driven type of transformation programme [172].