Chromosomal rearrangements leading to the convergence of EphA2-SE with a specific oncogene EphA2 might be another common mechanism to boost PI3K/AKT and Wnt/β-catenin pathways and be shared between several oncological nosologies, namely colorectal cancer, breast cancer, cervical cancer, etc. [120]. The gene discussed is EPHA2; the disease is breast carcinoma.