Reduced BMF-SE activity in chronic lymphocytic leukaemia (CLL) due to carrying the rs539846 risk allele (A) at the RELA binding site leads to the disruption of RELA binding, decreased BMF expression, and, therefore, BMF’s inability to inhibit the antiapoptotic protein BCL2. The gene discussed is RELA; the disease is B-cell chronic lymphocytic leukemia.