KMT2A and acute myeloid leukemia: SEs, acquired or lost due to chromosomal rearrangements, were extensively identified in haematological malignancies, namely t(3;8)(q26;q24) AML [108], inv(3)/t(3;3) AML [116,117] (Figure 5), AML with MLL rearrangements [118], multiple myeloma, and, in one solid cancer, fusion-positive rhabdomyosarcoma [119].