Relocation of the GATA2 enhancer element from the 3q21 to the 3q26.2 loci results in EVI1-SE formation and GATA2-SE loss in inv(3)/t(3;3) AML, leading to EVI1 upregulation and haploinsufficiency of GATA2, respectively. Here, RUNX1 is linked to acute myeloid leukemia.