A ChIP-seq of (acK13)-HOXB13, HOXB13, and H3K27ac signals analysis in tumour and normal samples has revealed that (acK13)-HOXB13 occupies an SE targeting lineage (AR, HOXB13), CRPC promoting (ACK1), prostate cancer diagnostic (FOLH1, SPON2), and angiogenesis-related (VEGFA) genes in cancer samples. Here, HOXB13 is linked to prostate cancer.