TP53 and Familial prostate cancer: Other frequently occurring genes include TP53 (as well as TP73, a TP53 family SE-associated gene present in adult T-cell leukaemia/lymphoma [156] and TP63), AR [157], ERG, ETS (ETV1, ETV4 [158], and ETV6) and IRF (IRF1, IRF2, IRF4 [159], and IRF8) family members, etc. Notably, TFs, like ERG, androgen receptor (AR), and ETV1, are commonly observed in prostate cancer, while TP53 and MYC are frequently involved in multiple cancer types.