Interestingly, mutations and deletions in TP53, a gene encoding the p53 protein guarding genome stability, were significantly enriched in HCC patients with CDK7, BRD4, EP300, and MED1 overexpression, which indicates a possible association between TP53 sequence alterations and upregulation of SE complex trans-acting components. The gene discussed is BRD4; the disease is hepatocellular carcinoma.