We selected several oncogenes and one tumor suppressor gene, showing deregulation by HMGB proteins (Figure 2), for independent validation after HMGB1 or HMGB2 shRNA silencing or overexpression in PC-3, considered the model of SCNC PCa [4], and in the LNCaP cell line, considered the adenocarcinoma model [20]. The gene discussed is HMGB1; the disease is posterior cortical atrophy.