In our previous work, we have already described that the transcriptional effect of silencing HMGB1 or HMGB2 is opposite for other target genes (i.e., DLAT, FLNA, MNAT1, MT2A, SNAPIN, UBE2E3, and UHRF2) encoding proteins that interact with HMGB proteins, and also for PMEPA1 or PSA, which are traditional biomarkers of PCa risk [18]. The gene discussed is HMGB1; the disease is posterior cortical atrophy.