Recently, the single-cell sequencing of PCa samples has brought into light that FN1 is highly expressed in a subtype of cancer-associated fibroblast (CAFs-C1) characterized in the PCa microenvironment, and a significant enrichment of CAFs-C1 is observed when comparing signatures in castration-resistant samples versus hormone-sensitive samples [35]. The gene discussed is FN1; the disease is posterior cortical atrophy.