In our previous work, we have already described that the transcriptional effect of silencing HMGB1 or HMGB2 is opposite for other target genes (i.e., DLAT, FLNA, MNAT1, MT2A, SNAPIN, UBE2E3, and UHRF2) encoding proteins that interact with HMGB proteins, and also for PMEPA1 or PSA, which are traditional biomarkers of PCa risk [18]. This evidence concerns the gene KLK3 and posterior cortical atrophy.