Relapsed DLBCL-NOS involving the ocular adnexa frequently presented pathogenic variants in PIM1 (3 of 6, 50%), CD79B (3 of 6, 50%), MYD88 (2 of 6, 33%), KLHL14 (2 of 6, 33%), BTG1 (2 of 6, 33%), BTG2 (2 of 6, 33%), HIST1H1E (2 of 6, 33%), TCF3 (2 of 6, 33%), ETV6 (2 of 6, 33%), and IRF4 (2 of 6, 33%). The gene discussed is CD79B; the disease is diffuse large B-cell lymphoma.