Several large genetic studies including both nodal and extranodal DLBCL-NOS have reported comparable mutational frequencies in PIM1 (11–28%), and slightly lower frequencies in CD79B (5–15%), TBL1XR1 (3–13%), and SETD1B (8–10%) [6,8,9,10,36]. The gene discussed is SETD1B; the disease is diffuse large B-cell lymphoma.