TBL1XR1 and diffuse large B-cell lymphoma: Nevertheless, in primary OA-DLBCL-NOS, we now identify frequent pathogenic variants in several of the genes that either link primary OA-DLBCL-NOS to the MCD subtype and NF-κB activation [7,8], or which are mutated in several of the abovementioned extranodal lymphomas [26,27,28,29,30,31,32,34,35], including CD79B (n = 3, 21%), the proto-oncogene PIM1 (n = 3, 21%), putative tumor suppressor TBL1XR1 (n = 3, 21%), and putative tumor suppressor SETD1B (n = 3, 21%).