Hyperglycemia, dyslipidemia, insulin resistance, and obesity upregulate the expression of MR, which elevates inflammatory (IL-1β, IL-6, TNF-α, MCP-1) and profibrotic factors (extracellular matrix proteins, PAI-1, TGF-β, CTGF), eventually resulting in the progression of DKD [145,146]. This evidence concerns the gene CCN2 and diabetic kidney disease.