Further investigation revealed that Toll-like receptor 3 (TLR3) and epidermal growth factor receptor (EGFR) were the key factors regulating the invasion and EMT capacity of lung cancer, as the inhibition of TLR3 or EGFR expression in cancer cells would significantly attenuate HPV-mediated lung cancer development [45,46]. The gene discussed is TLR3; the disease is lung cancer.