NF1 and neoplasm: Among all the heterogeneous features related to NF1, approximately 30–50% of individuals may develop plexiform neurofibromas (pNFs) [4,5], which are benign neoplasms, primarily originating from Schwann cells yet comprising a diverse array of other cell types, including fibroblasts, perineural cells and mast cells, resulting in a heterogeneous tumor microenvironment [6].