An illustrative instance involves the CASQ2-dependent form of CPVT, where the delivery of a functional wild-type (WT) CASQ2 seeks to replace the absent or dysfunctional gene, hypothesized to reinstate the normal cascade of Ca2+-induced Ca2+ release [144,145,146]. The gene discussed is CASQ2; the disease is catecholaminergic polymorphic ventricular tachycardia.