Approximately 30% of individuals diagnosed with CPVT have a family history of stress-related syncope, seizure or sudden cardiac death in relatives who were younger than 40 years old, with the prevalence of such events noted to be as high as 60% among families hosting RyR2 mutations [10,12]. The gene discussed is RYR2; the disease is catecholaminergic polymorphic ventricular tachycardia.