This study focused on 399 patients with PE and symptomatic DVT at high severity risk (age > 75 years, active cancer, respiratory failure, ischemic stroke with paralysis of a lower limb in the last 6 months, bilateral DVT, iliac vein or IVC thrombosis, presence of at least one sign of ventricular dysfunction or myocardial injury: right ventricle dilation, pulmonary hypertension, high levels of BNP, NT-proBNP, Troponine T or Troponine I). This evidence concerns the gene NPPB and ischemic stroke.