SERPINE1 and hyperthyroidism: It is believed that the emergence of a prothrombotic (hypercoagulable and hypofibrinolytic) state in hyperthyroidism is significantly contributed to by an elevated level of factor VIII (FVIII), von Willebrand factor (vWF), fibrinogen, and plasminogen activator inhibitor-1 (PAI-1), the level of which increases gradually with the level of thyroid hormones [2,3,4,5].