This indicates that there are patients with possible ADPKD who may have mild variants in PKD1 or PKD2 or variants in other ADPKD genes such as GANAB or DNAJB11, because only 18% of patients have probably pathogenic nonsense variants in PKD1, according to Lanktree et al. [8]. The gene discussed is PKD1; the disease is autosomal dominant polycystic kidney disease.