Some of these genes are known to produce proteins that play a key role in PRR signalling (NFkB family) or CTL and NK cytotoxicity (TWEAK), whilst their dysfunction can lead to anti-cytokine antibodies, or dysfunction of cytotoxic mechanisms, emphasising the spectrum of vulnerabilities in the CVID cohort and the benefit of assessing specific immunophenotypes [51,58,60]. Here, TNFSF12 is linked to common variable immunodeficiency.