Most recently, and in the first reported case to discuss the role of highly active antiretroviral therapy (HAART), a male diagnosed with CVID treated with IgRT was later noted to have raised IgG (43.9 g/L) and IgM (1.3 g/L) with persistent low IgA and IgE levels, and HIV was subsequently diagnosed. The gene discussed is CD79A; the disease is common variable immunodeficiency.