Certainly, cellular immunity seems to play a prominent role in HSV suppression, as evidenced by the severity of disease in acquired immunodeficiency syndrome (AIDS) secondary to human immunodeficiency virus (HIV), severe combined immunodeficiency (SCID), and other immunodeficiencies primarily affecting T-cell and NK cell function (e.g., GATA2 deficiency) [54,116,117]. Here, GATA2 is linked to severe combined immunodeficiency.