In another report, an 18-year old NFKB2-deficient CVID patient developed HSV-1 positive herpes vegetans that at first responded to intravenous (IV) foscarnet, before later recurrence and subsequent viraemia, that required a further intravenous course, followed by oral valaciclovir [120]. This evidence concerns the gene NFKB2 and common variable immunodeficiency.