The cases reported by Masuda et al. and Gunaydin et al. seem more compatible with isolated episodes of cardiac anaphylaxis than the cases of recurrent Kounis syndrome, considering that NSAIDs are well known to cause Kounis syndrome via hypersensitivity mechanism, which can be IgE-mediated or not, and bee sting is a very common cause of anaphylaxis [4,22,30]. This evidence concerns the gene IGHE and anaphylaxis.