If HF is present, patients should receive appropriate therapy including a β1-selective blocker, diuretics, angiotensin-converting enzyme (ACE) inhibitors, or, better, angiotensin receptor blockers (ARBs), angiotensin receptor neprilysin inhibitors (ARNIs), and/or sodium–glucose co-transporter 2 inhibitors (SGLT2-is). This evidence concerns the gene SLC5A2 and hydrops fetalis.