Systemic release of various proinflammatory, profibrogenic, pro-oxidant, and procoagulant mediators, such as interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), transforming growth factor-β (TGF-β), C-reactive protein (CRP), plasminogen activator inhibitor-1 (PAI-1), and fibrinogen, in steatotic and inflamed livers can contribute to CKD development [37,38,39]. Here, SERPINE1 is linked to chronic kidney disease.