Atrial fibrillation (AF), Bruton’s tyrosine kinase (BTK), bispecific antibodies (BsAbs), chimeric antigen receptor (CAR-T), cytokine release syndrome (CRS), left ventricular ejection fraction (LVEF), Janus kinases (JAK), histone deacetylase (HDAC), monoclonal antibodies (MoAbs), immunomodulatory (IMiDs), heart failure (HF). This evidence concerns the gene BTK and atrial fibrillation.