Starting from the premise developed in a study on lupus erythematosus systemic patients by Derksen et al. that stated that decreased levels of dehydroepiandrosterone (DHEA) and its sulfate ester (DHEAS) might impact fatigue and functionality [57], Hartkamp et al. conducted a comparative study between the levels of DHEAS in women with pSS and healthy control subjects. This evidence concerns the gene SULT2A1 and lupus erythematosus.