Core targets identified in the protein–protein interaction (PPI) network included ESR1 (Estrogen Receptor 1), MYC (Myelocytomatosis oncogene), HIF1A (Hypoxia Inducible Factor 1 Alpha), EGFR (Epidermal Growth Factor Receptor), VEGFA (Vascular Endothelial Growth Factor A), and CCND1 (Cyclin D1), representing key molecular pathways in breast cancer development and progression. This evidence concerns the gene ESR1 and breast carcinoma.