CXCL12 and breast carcinoma: On the other hand, miR-141 inhibition in these cells increases the expression of transcription factor 12 (TCF12) to facilitate the growth of breast cancer cells through CXCL12 secretion in CAFs, which leads to increased c-Myc and cyclin D1 expression in breast cancer cells, thus allowing these cells to undergo immortality through c-Myc activation [135].