ESR1 and breast cancer: Alcohol consumption has been related to higher BCR, principally for estrogen receptor-positive (ER+) BCs [133], through stimulation of migration and invasion of MCF7 human BC cells [133], EMT, angiogenesis, OS and ROS production [49,50], decreasing E-cadherin, α, β, and γ catenin expression, as well as BRCA1 tumor suppressor gene expression [133].