At a biologic pathway level, most xenobiotics interact with endocrine signaling, adipogenesis, angiogenesis, DNA repair, inflammatory response, IGF-1 and NF-κB signaling, epithelial–mesenchymal transition (EMT), Wnt/β-catenin pathway, PI3K/Akt signaling, fatty acid metabolism (FAM) and glycolysis, MAPK, STAT3, p53 pathway, MYC targets, xenobiotic metabolism, and other cancer-related pathways. This evidence concerns the gene STAT3 and cancer.