ADRB2 and neoplasm: After analyzing the integrated optical density of beta 2 adrenoreceptors for the patients included in our study, we observed increased IOD values in patients with tumors larger than 5 cm in diameter (p = 0.0371), with a deeper degree of tumor invasion T3–4 (p = 0.0159), invasion in more than two lymph nodes (p = 0.0462), or a TNM stage III–IV (p = 0.0119).