POMC and ovarian neoplasm: Endogenous factors with neoplasia include androgen-producing benign and malignant neoplasms of the ovaries and adrenal glands (adenomas and carcinomas), the pituitary gland, and the hypothalamus, as well as paraneoplastic syndromes, such as the production of the adrenocorticotropic hormone (ACTH) by a bronchial carcinoma.