Furthermore, Marina et al. investigated the relationship between LH and insulin resistance (IR); adrenal tumour size (ATS) and IR; and LH and cortisol and concluded that there is clinical evidence showing that the enhanced adrenal cortex steroid production in female patients with adrenal tumours and mild autonomous cortisol secretion is a result of the synergistic action of LH and insulin, which means that endocrine interactions with gonadal hormones need to be taken into consideration [11]. The gene discussed is PLOD1; the disease is adrenal gland neoplasm.