In this work, various inhibitors of SOCE were studied in two BC cell lines with polar SOCE molecular composition: (1) the TNBC line MDA-MB-231 with predominant expression of Orai1, and (2) the luminal A BC line MCF7 in which SOCE is mainly determined by Orai3 proteins [24,25]. Here, ORAI1 is linked to breast cancer.