ERBB2 and breast cancer: We explored the effect of several external factors and inhibitory compounds on SOCE in three cell lines: the MCF-10A control cell line of a non-oncogenic nature, the HER2-negative ER-positive BC cell line MCF-7 with increased expression of Orai3 channels, and the TNBC MDA-MB-231 cell line with increased expression of Orai1 channels.