transient ischemic event; stented stenosis of left ICA; quadruple CABG; large spontaneous gluteal bleed while on aspirin without FVIII prophylaxis; congestive HF; left ventricular dysfunction; type 2 diabetes mellitus; essential hypertension; hiatus hernia repair; cholecystectomy; bilateral total hip replacement and subsequent revision. This evidence concerns the gene F8 and essential hypertension.