The rationale for selecting IL-4, IL-5, IL-6, IL-9, IL-13, IL-25, IL-31, IL-33, and TSLP is that these cytokines induce the type 2 allergic immune responses associated with atopic dermatitis, asthma, allergic rhinitis, and allergic conjunctivitis [22]. The gene discussed is IL33; the disease is atopic conjunctivitis.