It was demonstrated that fibroblasts found in the tumor environment called carcinoma-associated fibroblasts (CAFs) specifically express smooth muscle actin, EGF, HGF, IGF-1 and -2, and matrix remodeling enzymes such as MMPs, demonstrating the importance of tumor stroma, and CAFs in particular, to the process of tumor progression [11]. Here, IGF1 is linked to neoplasm.