It was concluded that magnolol inhibited mast cell accumulation in a murine atopic dermatitis model and that the efficacy was likely due to the inhibition of pro-inflammatory cytokines in the skin (IL-17A, IL-4, IL-13, IFN-γ, and IL-12A) as well as chemokines (TARC, IL-8, and IL-6) in lymph nodes and epidermis. This evidence concerns the gene IL12A and atopic eczema.