HIIT intervention reduced myocardial infarct size, decreased serum concentrations of troponin-I and LDH associated with myocardial infarction, and also reduced serum levels of TNF-α, IL-1β, and IL-6 while increasing the anti-inflammatory cytokine IL-10, demonstrating similar myocardial protective effects as IPC. This evidence concerns the gene IL1B and myocardial infarction.