The Wingless-type (Wnt) signaling pathway and its inhibitors sclerostin (SOST) and dickkopf-1 (DKK-1) have been identified as central regulators of bone and cartilage formation [5,6], while dysregulation of this signaling pathway has been implicated in many bone tissue disorders such as osteoporosis [7,8], as well as periodontitis [9,10]. The gene discussed is SOST; the disease is periodontitis.