DKK1 and diabetes mellitus: Also, contrary to the mentioned study, the values of DKK-1 were elevated in the SP group and statins did not decrease DKK-1 levels, probably due to the presence of more patients with a higher grade of disease and diabetes in the SP group compared with the P group This is consistent with a study by Crandall et al. [51] which concluded that statins can increase the risk of diabetes (10–12%) when compared to a placebo, as well as Corrao et al. which stated that even for the development of a new state of diabetes, statins (all doses) can increase the risk of developing diabetes by 32% [52].