To our knowledge, this is the first study that investigated the following six SNPs (XPC 1496C>T, XPC 2920A>C, XPD 2251A>C, XPF-673C>T, XPF 11985A>G, and XPG 3507G>C) involved in the etiology of MPN patients and also analyzed the relation between investigated polymorphisms and JAK2-V617F or CALR driver mutations. The gene discussed is XPC; the disease is myeloproliferative neoplasm.