Also, male gender (p < 0.001), positive CALR mutation (p < 0.001), smoking (p = 0.023), hemoglobin value > 16.5 g/dL, platelet value > 450 × 109/L (p < 0.001), and palpable splenomegaly (p = 0.001) were predictors in the group of patients with ET, while in the group of patients with PV, only male gender (p < 0.001), positive CALR mutation (p < 0.001), smoking (p = 0.035), and hemoglobin value > 16.5 g/dL were predictors. The gene discussed is CALR; the disease is Splenomegaly.