Based on the data obtained in the current study, we consider that XPD 2251A>C may influence MPN and that XPF-673C>T and XPF 11985A>G single nucleotide polymorphisms (SNPs) had a protective role for MPN, while XPC 1496C>T, XPC 2920A>C, and XPG 3507G>C polymorphisms do not represent risk factors in MPN development. The gene discussed is XPC; the disease is myeloproliferative neoplasm.