In the group of patients with ET, male gender (p < 0.001), hemoglobin value > 16.5 g/dL (p < 0.001, positive CALR mutation (p < 0.001, smoking (p = 0.023), palpable splenomegaly (p = 0.001), and platelets > 450 × 109/L (p < 0.001) were predictors. Here, CALR is linked to Splenomegaly.