Additionally, in breast cancer, there’s evidence of alteration in metabolism to a glycolytic type through the transforming growth factor-β (TGF-β)-STAT1-succinate dehydrogenase (SDH)-hypoxia-inducible factor 1α (HIF1α) pathway, both in ex vivo and in vivo murine models [92]. The gene discussed is TGFB1; the disease is breast cancer.