Furthermore, in mice, treated with the tobacco smoke carcinogen 4-(methylnitrosamino)-1- (3-pyridyl)-1-butanone (NNK) and lipopolysaccharide, the abundance of TAMs (M2 macrophages phenotype), PD-L1+ tumour cells, Foxp3+CD4+ T cells, and CD8+ T cells was higher compared with NNK-induced tumours [73]. This evidence concerns the gene CD4 and neoplasm.