CD4 and neoplasm: This data confirms that TILs and M2 macrophages crosstalk in the TME affects the expression of PD-L1 on tumour cells and immune cells, leading to hypothesis that PD-L1 expression assessment in concern of TILs (CD4+ T cells, Foxp3+CD4+ T cells, and CD8+ T cells) and TAMs (M2 macrophages) may provide additional benefit selecting patients for immunotherapy.