CFTR and cystic fibrosis-related diabetes: Several risk factors have been associated with the development of CFRD including organ insufficiency (lung, liver, exocrine pancreas), growth delay, sex (female), residual CFTR function-related factors (residual function, genotype, genetic modifiers), history of solid organ transplantation, abnormal glucose tolerance (impaired fasting glucose, impaired glucose tolerance, indeterminate), and medication use (corticosteroids, calcineurin inhibitors) [12].