INS and diabetes mellitus: Strict blood glucose control is important to prevent micro- and macro-vascular diabetic complications in patients with diabetes [1,2] However, the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial, in which the efficiency of the normalization of blood glucose levels via insulin or sulfonylurea was evaluated, revealed that mortality increased through the normalization of hemoglobin A1c (HbA1c) levels via insulin or sulfonylurea [3].