IL18 and diabetes mellitus: They found that the levels of several inflammatory and immune biomarkers (i.e., white blood cells, granulocytes (primarily neutrophils), monocytes, interleukin (IL)-1 receptor antagonist, IL-18, and fibrinogen) increased when examining the progression from normoglycemia to prediabetes to diabetes, they found an increase in lymphocytes and c-reactive protein from normoglycemia to prediabetes, and an increase in neopterin concentrations from prediabetes to diabetes [34].